Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells.
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ABSTRACT:
SUBMITTER: Luo LX
PROVIDER: S-EPMC6071735 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells.
Luo Lian-Xiang LX Fan Xing-Xing XX Li Ying Y Peng Xia X Ji Yin-Chun YC Hsiao Wendy Wen-Luan WW Liu Liang L Leung Elaine Lai-Han EL Yao Xiao-Jun XJ
MedChemComm 20170126 3
Mitoxantrone, an FDA-approved drug for multiple sclerosis and hormone refractory prostate cancer, is identified as a potent inhibitor of ROS1 fusion protein by <i>in silico</i> screening in non-small cell lung cancer cells. Mitoxantrone can suppress the phosphorylation of ROS1 and subsequently inhibit its downstream signaling pathway and thus induce cell apoptosis. ...[more]
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