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Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells.


ABSTRACT: Mitoxantrone, an FDA-approved drug for multiple sclerosis and hormone refractory prostate cancer, is identified as a potent inhibitor of ROS1 fusion protein by in silico screening in non-small cell lung cancer cells. Mitoxantrone can suppress the phosphorylation of ROS1 and subsequently inhibit its downstream signaling pathway and thus induce cell apoptosis.

SUBMITTER: Luo LX 

PROVIDER: S-EPMC6071735 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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