Ontology highlight
ABSTRACT:
SUBMITTER: Salah M
PROVIDER: S-EPMC6071757 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
MedChemComm 20180528 6
We present the development of conformationally pre-organised Dyrk1A inhibitors based on the hydroxybenzothiazole urea scaffold. The modifications introduced to the discovered hit (AHS-211) proved the crucial role of the urea linker to preserve the bioactive conformation and led to the development of compound <b>b5</b> as a promising selective Dyrk1A inhibitor. ...[more]