Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.

ABSTRACT: BACKGROUND:Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE:Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS:We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan-IQ associations at each visit. We also tested whether associations between tricl

SUBMITTER: Jackson-Browne MS 

PROVIDER: S-EPMC6072011 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature