Ontology highlight
ABSTRACT:
SUBMITTER: Kumar C
PROVIDER: S-EPMC6072283 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Kumar Chetan C Rasool Reyaz Ur RU Iqra Zainab Z Nalli Yedukondalu Y Dutt Prabhu P Satti Naresh K NK Sharma Neha N Sharma Neha N Gandhi Sumit G SG Goswami Anindya A Ali Asif A
MedChemComm 20171102 11
Herein, we report the isolation and synthetic modification of dehydrozingerone (DHZ, <b>1</b>), a secondary metabolite present in the rhizome of <i>Zingiber officinale</i>. We synthesized <i>O</i>-propargylated dehydrozingerone, which was subsequently coupled by alkyne-azide cycloaddition (<b>3-20</b>) using click chemistry. The compounds (<b>1-20</b>) were evaluated for their <i>in vitro</i> cytotoxic activity in a panel of three cancer cell lines. Among all the DHZ derivatives, <b>3</b>, <b>6< ...[more]