Ontology highlight
ABSTRACT:
SUBMITTER: Shuto Y
PROVIDER: S-EPMC6072303 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
MedChemComm 20170317 5
The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity over related receptors was investigated. The synthesis of <b>5a</b> and <b>5b</b> was performed by reductive amination of the ketone <b>6</b> with primary alkanamines <b>14a</b> and <b>14b</b> bearing an F-atom in β-position. The GluN2B affinities of non-fluorinated and fluorinated ligands <b>4</b> and <b>5</b> are almost identical. The low ...[more]