Ontology highlight
ABSTRACT:
SUBMITTER: Inceler N
PROVIDER: S-EPMC6072348 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Inceler Nazan N Ozkan Yesim Y Turan Nilufer Nermin NN Kahraman Deniz Cansen DC Cetin-Atalay Rengul R Baytas Sultan Nacak SN
MedChemComm 20180406 5
With the aim of achieving new compounds possessing both anti-inflammatory and antiplatelet activities, we synthesized (<i>E</i>)-3-[3-(pyridin-3/4-yl)-1-(phenyl/sulfonylmethylphenyl)-1<i>H</i>-pyrazol-4-yl]acrylamides, and evaluated their COX-1 and COX-2 inhibitory and antiplatelet activities. Since COX-2 inhibitory and antiplatelet compounds have anticancer potential, we also screened their antiproliferative effects against three human cancer cell lines. Compounds <b>5n</b>, <b>5p</b>, <b>5s</b ...[more]