Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides.
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ABSTRACT:
SUBMITTER: Towle KM
PROVIDER: S-EPMC6072434 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides.
MedChemComm 20170111 2
Bacteriocins are potent antimicrobial peptides that are ribosomally produced and exported by bacteria, presumably to aid elimination of competing microorganisms. Many circular and linear leaderless bacteriocins have a recuring three dimensional structural motif known as a saposin-like fold. Although these bacteriocin sizes and sequences are often quite different, and their mechanisms of action vary, this conserved motif of multiple helices appears critical for activity and may enable peptide-lip ...[more]
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