Ontology highlight
ABSTRACT:
SUBMITTER: Antony J
PROVIDER: S-EPMC6073217 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Antony Jane J Zanini Elisa E Kelly Zoe Z Tan Tuan Zea TZ Karali Evdoxia E Alomary Mohammad M Jung Youngrock Y Nixon Katherine K Cunnea Paula P Fotopoulou Christina C Paterson Andrew A Roy-Nawathe Sushmita S Mills Gordon B GB Huang Ruby Yun-Ju RY Thiery Jean Paul JP Gabra Hani H Recchi Chiara C
EMBO reports 20180615 8
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the ...[more]