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New Insights in Anti-Angiogenesis in Multiple Myeloma.


ABSTRACT: Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma.

SUBMITTER: Ribatti D 

PROVIDER: S-EPMC6073492 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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New Insights in Anti-Angiogenesis in Multiple Myeloma.

Ribatti Domenico D   Vacca Angelo A  

International journal of molecular sciences 20180712 7


Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma. ...[more]

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