Ontology highlight
ABSTRACT:
SUBMITTER: Parsa JY
PROVIDER: S-EPMC6075038 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Genes & development 20180701 13-14
In <i>Schizosaccharomyces pombe</i>, transcripts derived from the pericentromeric <i>dg</i> and <i>dh</i> repeats promote heterochromatin formation via RNAi as well as an RNAi-independent mechanism involving the RNA polymerase II (RNAPII)-associated RNA-binding protein Seb1 and RNA processing activities. We show that Seb1 promotes long-lived RNAPII pauses at pericentromeric repeat regions and that their presence correlates with the heterochromatin-triggering activities of the corresponding <i>dg ...[more]