Ontology highlight
ABSTRACT:
SUBMITTER: Schilbach S
PROVIDER: S-EPMC6078178 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature 20171101 7679
For the initiation of transcription, RNA polymerase II (Pol II) assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we report cryo-electron microscopy structures of the Saccharomyces cerevisiae PIC and PIC-core Mediator complex at nominal resolutions of 4.7 Å and 5.8 Å, respectively. The structures reveal transcription factor IIH (TFIIH), and suggest how the core and kinase TFIIH modules function in the opening of promoter DNA and the phosp ...[more]