Ontology highlight
ABSTRACT:
SUBMITTER: Xin D
PROVIDER: S-EPMC6078441 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20180614 31
Chronic neuroinflammation is a characteristic of Parkinson's disease (PD). Previous investigations have shown that Parkin gene mutations are related to the early-onset recessive form of PD and isolated juvenile-onset PD. Further, Parkin plays important roles in mitochondrial quality control and cytokine-induced cell death. However, whether Parkin regulates other cellular events is still largely unknown. In this study, we performed overexpression and knockout experiments and found that Parkin neg ...[more]