Ontology highlight
ABSTRACT:
SUBMITTER: Yang B
PROVIDER: S-EPMC7069649 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yang Bo B Liu Yue Y Cui Yuhan Y Song Di D Zhang Ge G Ma Shujun S Liu Yanzi Y Chen Mengmeng M Chen Fan F Wang Hui H Wang Jie J
PLoS pathogens 20200303 3
Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is essential to DNA virus- or cytosolic DNA-triggered innate immune responses. In this study, we demonstrated the negative regulatory role of RING-finger protein (RNF) 90 in innate immune responses targeting MITA. RNF90 promoted K48-linked ubiquitination of MITA and its proteasome-dependent degradation. Overexpression of RNF90 inhibited HSV-1- or cytosolic DNA-induced immune responses whereas RNF90 knockdown had the oppos ...[more]