Ontology highlight
ABSTRACT:
SUBMITTER: Kassam I
PROVIDER: S-EPMC6078603 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kassam Irfahan I Qi Tuan T Lloyd-Jones Luke L Holloway Alexander A Jan Bonder Marc M Henders Anjali K AK Martin Nicholas G NG Powell Joseph E JE Franke Lude L Montgomery Grant W GW Visscher Peter M PM McRae Allan F AF
Human molecular genetics 20161201 24
The mitochondrial and nuclear genomes coordinate and co-evolve in eukaryotes in order to adapt to environmental changes. Variation in the mitochondrial genome is capable of affecting expression of genes on the nuclear genome. Sex-specific mitochondrial genetic control of gene expression has been demonstrated in Drosophila melanogaster, where males were found to drive most of the total variation in gene expression. This has potential implications for male-related health and disease resulting from ...[more]