Dataset Information

Association between IL-1??+?3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

ABSTRACT: Many studies have reported that the IL-1??+?3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1??+?3954C/T and MI susceptibility, we performed a meta-analysis.We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1??+?3954C/T in an allelic comparison (T vs C: OR?=?1.13, 95% CI 1.02-1.25, I?=?0%, PH?=?.448) and in a dominant model (TC?+?TT vs CC: OR?=?1.15, 95% CI 1.02-1.30, I?=?0%, PH?=?.880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR?=?1.16, 95% CI 1.04-1.29, I?=?0%, PH?=?.701), homozygote model (TT vs CC: OR?=?1.36, 95% CI 1.04-1.79, I?=?0%, PH?=?.673), and dominant model (TC?+?TT vs CC: OR?=?1.17, 95% CI 1.02-1.33, I?=?0%, PH?=?.851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data.Our meta-analysis proved that IL-1??+?3954C/T is associated with MI susceptibility, especially among Caucasian populations.

SUBMITTER: Fang Y

PROVIDER: S-EPMC6078675 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

Fang Yizhen Y Xie Huabin H Lin Zhiyuan Z

Medicine 20180701 30

<h4>Background</h4>Many studies have reported that the IL-1β + 3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1β + 3954C/T and MI susceptibility, we performed a meta-analysis.<h4>Methods</h4>We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sen ...[more]

PMID: 30045312

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Project description:BackgroundAccumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population.MethodsGenotyping was performed in 287 MI cases and 646 control subjects using polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The association of these SNPs with MI risk was performed with SPSS software.ResultsIn a logistic regression analysis, we found that AG heterozygote (OR = 0.40, 95% CI = 0.21-0.76, Pa = 0.005) or AA homozygote (OR = 0.40, 95% CI = 0.22-0.75, Pa = 0.004) of pre-miR-27a rs895819 had a reduced susceptibility to MI in comparison with GG homozygote. Similarly, a reduced risk of MI was detected when the AG and AA genotypes were combined (OR = 0.40, 95% CI = 0.22-0.74, Pa = 0.003). However, no significant association between pri-miR-26a-1 pri-miR-100, pri-miR-126 and pri-miR-218 polymorphisms and MI risk was observed under the allelic and established genetic models. Further stratified analysis of pre-miR-27a rs895819 revealed a more significant association of AG + AA genotypes with MI risk among younger, male and smoking subjects. Interestingly, AG and AA genotypes of the rs895819 polymorphism conferred about 0.17 mmol/L and 0.18 mmol/L increase in HDL-C levels compared to GG genotype.ConclusionsOur findings suggest that the pre-miR-27a rs895819 polymorphism is associated with MI susceptibility in the Chinese Han population, which probably due to influence the HDL-C levels.

Dataset Information

Association between IL-1??+?3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

Publications

Association between IL-1β + 3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

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