Association between IL-1??+?3954C/T polymorphism and myocardial infarction risk: A meta-analysis.

ABSTRACT: Many studies have reported that the IL-1??+?3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1??+?3954C/T and MI susceptibility, we performed a meta-analysis.We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1??+?3954C/T in an allelic comparison (T vs C: OR?=?1.13, 95% CI 1.02-1.25, I?=?0%, PH?=?.448) and in a dominant model (TC?+?TT vs CC: OR?=?1.15, 95% CI 1.02-1.30, I?=?0%, PH?=?.880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR?=?1.16, 95% CI 1.04-1.29, I?=?0%, PH?=?.701), homozygote model (TT vs CC: OR?=?1.36, 95% CI 1.04-1.79, I?=?0%, PH?=?.673), and dominant model (TC?+?TT vs CC: OR?=?1.17, 95% CI 1.02-1.33, I?=?0%, PH?=?.851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data.Our meta-analysis proved that IL-1??+?3954C/T is associated with MI susceptibility, especially among Caucasian populations.

SUBMITTER: Fang Y 

PROVIDER: S-EPMC6078675 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature