Ontology highlight
ABSTRACT:
SUBMITTER: Piragyte I
PROVIDER: S-EPMC6078963 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Piragyte Indre I Clapes Thomas T Polyzou Aikaterini A Klein Geltink Ramon I RI Lefkopoulos Stylianos S Yin Na N Cauchy Pierre P Curtis Jonathan D JD Klaeylé Lhéanna L Langa Xavier X Beckmann Cora C A CCA Wlodarski Marcin W MW Müller Patrick P Van Essen Dominic D Rambold Angelika A Kapp Friedrich G FG Mione Marina M Buescher Joerg M JM Pearce Erika L EL Polyzos Alexander A Trompouki Eirini E
Nature communications 20180806 1
The H2.0-like homeobox transcription factor (HLX) regulates hematopoietic differentiation and is overexpressed in Acute Myeloid Leukemia (AML), but the mechanisms underlying these functions remain unclear. We demonstrate here that HLX overexpression leads to a myeloid differentiation block both in zebrafish and human hematopoietic stem and progenitor cells (HSPCs). We show that HLX overexpression leads to downregulation of genes encoding electron transport chain (ETC) components and upregulation ...[more]