Ontology highlight
ABSTRACT:
SUBMITTER: Lee PY
PROVIDER: S-EPMC6953719 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lee Pui Y PY Sykes David B DB Ameri Sarah S Kalaitzidis Demetrios D Charles Julia F JF Nelson-Maney Nathan N Nelson-Maney Nathan N Wei Kevin K Cunin Pierre P Morris Allyn A Cardona Astrid E AE Root David E DE Scadden David T DT Nigrovic Peter A PA
Science immunology 20170501 11
Monocytes are derived from hematopoietic stem cells through a series of intermediate progenitor stages, but the factors that regulate this process are incompletely defined. Using a Ccr2/Cx<sub>3</sub>cr1 dual-reporter system to model murine monocyte ontogeny, we conducted a small-molecule screen that identified an essential role of mechanistic target of rapamycin complex 1 (mTORC1) in the development of monocytes and other myeloid cells. Confirmatory studies using mice with inducible deletion of ...[more]