Ontology highlight
ABSTRACT:
SUBMITTER: Bansal V
PROVIDER: S-EPMC6079028 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bansal V V Mitjans M M Burik C A P CAP Linnér R K RK Okbay A A Rietveld C A CA Begemann M M Bonn S S Ripke S S de Vlaming R R Nivard M G MG Ehrenreich H H Koellinger P D PD
Nature communications 20180806 1
Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium ...[more]