Genome-wide identification of directed gene networks using large-scale population genomics data.
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ABSTRACT:
SUBMITTER: Luijk R
PROVIDER: S-EPMC6079029 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Genome-wide identification of directed gene networks using large-scale population genomics data.
Luijk René R Dekkers Koen F KF van Iterson Maarten M Arindrarto Wibowo W Claringbould Annique A Hop Paul P Boomsma Dorret I DI van Duijn Cornelia M CM van Greevenbroek Marleen M J MMJ Veldink Jan H JH Wijmenga Cisca C Franke Lude L 't Hoen Peter A C PAC Jansen Rick R van Meurs Joyce J Mei Hailiang H Slagboom P Eline PE Heijmans Bastiaan T BT van Zwet Erik W EW
Nature communications 20180806 1
Identification of causal drivers behind regulatory gene networks is crucial in understanding gene function. Here, we develop a method for the large-scale inference of gene-gene interactions in observational population genomics data that are both directed (using local genetic instruments as causal anchors, akin to Mendelian Randomization) and specific (by controlling for linkage disequilibrium and pleiotropy). Analysis of genotype and whole-blood RNA-sequencing data from 3072 individuals identifi ...[more]
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