Unknown

Dataset Information

0

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

ABSTRACT: Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with 6,669 breast cancer patients and 21,930 female controls in the Japanese population. This GWAS identified 11 genomic loci that surpass genome-wide significance threshold of P?

SUBMITTER: Low SK 

PROVIDER: S-EPMC6874604 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association studies (GWAS) have successfully identified about 70 genomic loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and environmental exposures in different populations, it is essential to perform regional GWAS for better risk prediction. This study aimed to investigate the genetic architecture and to assess common genetic risk model of breast cancer with 6,669 breast cancer patients and 21,930 female controls in the Japanese population. Thi  ...[more]

Similar Datasets

Unknown Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
| S-EPMC7968075 | biostudies-literature
Unknown Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population.
| S-EPMC5857507 | biostudies-literature
Unknown Genome-wide association study identifies new loci for albuminuria in the Japanese population.
| S-EPMC7994224 | biostudies-literature
Unknown Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
| S-EPMC3080658 | biostudies-literature
Unknown Genome-wide association study of breast cancer in the Japanese population.
| S-EPMC3797071 | biostudies-literature
Unknown Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
| S-EPMC3267376 | biostudies-literature
Unknown Integrative approaches for large-scale transcriptome-wide association studies.
| S-EPMC4767558 | biostudies-other
Unknown Genome-wide association study of susceptibility loci for breast cancer in Sardinian population.
| S-EPMC4434540 | biostudies-literature
Unknown Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
| S-EPMC4738362 | biostudies-literature
Unknown Longitudinal exome-wide association study to identify genetic susceptibility loci for hypertension in a Japanese population.
| S-EPMC5750474 | biostudies-literature