Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC6079368 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cheng Zhi Z Wei Runhong R Ma Qiuling Q Shi Lin L He Feng F Shi Zixiao Z Jin Tao T Xie Ronglin R Wei Baofeng B Chen Jing J Fang Hongliang H Han Xiaolu X Rohrs Jennifer A JA Bryson Paul P Liu Yarong Y Li Qi-Jing QJ Zhu Bo B Wang Pin P
Molecular therapy : the journal of the American Society of Gene Therapy 20180202 4
Several recent clinical trials have successfully incorporated a costimulatory domain derived from either CD28 or 4-1BB with the original CD3ζ T cell activating domain to form second-generation chimeric antigen receptors (CARs) that can increase the responsiveness and survival of CAR-engineered T (CAR-T) cells. However, a rigorous assessment of the individual benefits of these costimulatory components relative to the in vivo performance of infused T cells in patients is still lacking. Therefore, ...[more]