Ontology highlight
ABSTRACT:
SUBMITTER: Firbank SJ
PROVIDER: S-EPMC60802 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Firbank S J SJ Rogers M S MS Wilmot C M CM Dooley D M DM Halcrow M A MA Knowles P F PF McPherson M J MJ Phillips S E SE
Proceedings of the National Academy of Sciences of the United States of America 20011101 23
Galactose oxidase (EC ) is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes. The protein contains an unusual covalent thioether bond between a tyrosine, which acts as a radical center during the two-electron reaction, and a cysteine. The enzyme is produced in a precursor form lacking the thioether bond and also possessing an additional 17-aa pro-sequence at the N terminus. Previous work has shown ...[more]