Dataset Information

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.

ABSTRACT:

Background

We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria.

Methods

The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure is clinical progression.

Results

Cross-sectional evaluation of the first 151 participants (age 64?±?8, 44% female, Mini-Mental State Examination 29?±?2) showed that 28 (25%) had preclinical Alzheimer's disease (AD) (amyloid status available n?=?114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither. More severe subjective complaints were associated with worse objective performance. The SCD-plus criteria age???60 (OR 7.7 (95% CI 1.7-38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6-15.0)) were associated with preclinical AD.

Conclusions

The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features. We found a number of SCD-plus criteria to be associated with preclinical AD. Further inclusion and follow-up will address important questions related to SCD.

SUBMITTER: Slot RER

PROVIDER: S-EPMC6080529 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.

Slot Rosalinde E R RER Verfaillie Sander C J SCJ Overbeek Jozefien M JM Timmers Tessa T Wesselman Linda M P LMP Teunissen Charlotte E CE Dols Annemiek A Bouwman Femke H FH Prins Niels D ND Barkhof Frederik F Lammertsma Adriaan A AA Van Berckel Bart N M BNM Scheltens Philip P Sikkes Sietske A M SAM Van der Flier Wiesje M WM

Alzheimer's research & therapy 20180807 1

<h4>Background</h4>We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria.<h4>Methods</h4>The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure ...[more]

PMID: 30081935

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Dataset Information

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.

Background

Methods

Results

Conclusions

Publications

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.

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