Ontology highlight
ABSTRACT:
SUBMITTER: Wilson ZN
PROVIDER: S-EPMC6080712 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Wilson Zachary N ZN Scott Amber L AL Dowell Robin D RD Odorizzi Greg G
Molecular biology of the cell 20180523 13
Lysosomes are dynamic organelles with critical roles in cellular physiology. The lysosomal signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P<sub>2</sub>) is a key regulator that has been implicated to control lysosome ion homeostasis, but the scope of ion transporters targeted by PI(3,5)P<sub>2</sub> and the purpose of this regulation is not well understood. Through an unbiased screen in Saccharomyces cerevisiae, we identified loss-of-function mutations in the vacuolar H<sup>+</sup ...[more]