Ontology highlight
ABSTRACT:
SUBMITTER: Thieleke-Matos C
PROVIDER: S-EPMC4267720 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Traffic (Copenhagen, Denmark) 20140821 10
Malaria parasites go through an obligatory liver stage before they infect erythrocytes and cause disease symptoms. In the host hepatocytes, the parasite is enclosed by a parasitophorous vacuole membrane (PVM). Here, we dissected the interaction between the Plasmodium parasite and the host cell late endocytic pathway and show that parasite growth is dependent on the phosphoinositide 5-kinase (PIKfyve) that converts phosphatidylinositol 3-phosphate [PI(3)P] into phosphatidylinositol 3,5-bisphospha ...[more]