Ontology highlight
ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC6081238 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yan Jun J Bi Meng M Bourdon Allen K AK Farmer Abigail T AT Wang Po-Hsiang PH Molenda Olivia O Quaile Andrew T AT Jiang Nannan N Yang Yi Y Yin Yongchao Y Şimşir Burcu B Campagna Shawn R SR Edwards Elizabeth A EA Löffler Frank E FE
Nature chemical biology 20171106 1
Cobamides such as vitamin B<sub>12</sub> are structurally conserved, cobalt-containing tetrapyrrole biomolecules that have essential biochemical functions in all domains of life. In organohalide respiration, a vital biological process for the global cycling of natural and anthropogenic organohalogens, cobamides are the requisite prosthetic groups for carbon-halogen bond-cleaving reductive dehalogenases. This study reports the biosynthesis of a new cobamide with unsubstituted purine as the lower ...[more]