Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Botet A
PROVIDER: S-EPMC6081371 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Sánchez-Botet Abril A Gasa Laura L Quandt Eva E Hernández-Ortega Sara S Jiménez Javier J Mezquita Pau P Carrasco-García Miquel Àngel MÀ Kron Stephen J SJ Vidal August A Villanueva Alberto A Ribeiro Mariana P C MPC Clotet Josep J
Scientific reports 20180807 1
Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8-10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role of the new subfamily of atypical cyclins remains elusive. Here we have performed a systematic analysis of the protein expression levels of eight atypical cyclins in human CRC tumours and several cell lines, and found that CNTD2 is significantly upregulated in CRC tissue compared to the adjacent n ...[more]