Ontology highlight
ABSTRACT:
SUBMITTER: Gao F
PROVIDER: S-EPMC4770728 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Gao Fei F Huang Wei W Zhang YuQin Y Tang ShaoHui S Zheng Lin L Ma Feng F Wang YiMing Y Tang Hui H Li Xin X
Oncotarget 20151101 36
Hes1 is a transcription factor that influences cell proliferation and differentiation. However, the effect of Hes1 on invasiveness and the underlying mechanism remain unknown. In the current study, we found that Hes1 suppressed cell apoptosis, promoted cell growth, induced EMT phenotype and cytoskeleton reconstruction, and enhanced the metastatic potential of colon cancer cells in vitro and in vivo. Furthermore, we indicated that Bmi-1 mediated Hes1-induced cell proliferation and migration, down ...[more]