Ontology highlight
ABSTRACT:
SUBMITTER: Bryois J
PROVIDER: S-EPMC6081462 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bryois Julien J Garrett Melanie E ME Song Lingyun L Safi Alexias A Giusti-Rodriguez Paola P Johnson Graham D GD Shieh Annie W AW Buil Alfonso A Fullard John F JF Roussos Panos P Sklar Pamela P Akbarian Schahram S Haroutunian Vahram V Stockmeier Craig A CA Wray Gregory A GA White Kevin P KP Liu Chunyu C Reddy Timothy E TE Ashley-Koch Allison A Sullivan Patrick F PF Crawford Gregory E GE
Nature communications 20180807 1
Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified 118,152 ATAC-seq peaks. These accessible chromatin regions in the brain are highly enric ...[more]