Ontology highlight
ABSTRACT:
SUBMITTER: Paknejad N
PROVIDER: S-EPMC6082148 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Paknejad Navid N Hite Richard K RK
Nature structural & molecular biology 20180716 8
Inositol trisphosphate receptors (IP<sub>3</sub>Rs) are ubiquitous Ca<sup>2+</sup>-permeable channels that mediate release of Ca<sup>2+</sup> from the endoplasmic reticulum, thereby regulating numerous processes including cell division, cell death, differentiation and fertilization. IP<sub>3</sub>Rs are jointly activated by inositol trisphosphate (IP<sub>3</sub>) and their permeant ion, Ca<sup>2+</sup>. At high concentrations, however, Ca<sup>2+</sup> inhibits activity, ensuring precise spatiote ...[more]