Ontology highlight
ABSTRACT:
SUBMITTER: Natarajan P
PROVIDER: S-EPMC6082163 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Natarajan Pradeep P Jaiswal Siddhartha S Kathiresan Sekar S
Circulation. Genomic and precision medicine 20180701 7
The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk ...[more]