Ontology highlight
ABSTRACT:
SUBMITTER: Reardon CA
PROVIDER: S-EPMC6082182 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Reardon Catherine A CA Lingaraju Amulya A Schoenfelt Kelly Q KQ Zhou Guolin G Cui Chang C Jacobs-El Hannah H Babenko Ilona I Hoofnagle Andrew A Czyz Daniel D Shuman Howard H Vaisar Tomas T Becker Lev L
Cell reports 20180601 10
Type 2 diabetes (T2D) is associated with increased risk for atherosclerosis; however, the mechanisms underlying this relationship are poorly understood. Macrophages, which are activated in T2D and causatively linked to atherogenesis, are an attractive mechanistic link. Here, we use proteomics to show that diet-induced obesity and insulin resistance (obesity/IR) modulate a pro-atherogenic "macrophage-sterol-responsive-network" (MSRN), which, in turn, predisposes macrophages to cholesterol accumul ...[more]