Ontology highlight
ABSTRACT:
SUBMITTER: Hickman HD
PROVIDER: S-EPMC6082381 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hickman Heather D HD Mays Jacqueline W JW Gibbs James J Kosik Ivan I Magadán Javier G JG Takeda Kazuyo K Das Suman S Reynoso Glennys V GV Ngudiankama Barbara F BF Wei JiaJie J Shannon John P JP McManus Daniel D Yewdell Jonathan W JW
Journal of immunology (Baltimore, Md. : 1950) 20180716 4
Probing the limits of CD8<sup>+</sup> T cell immunosurveillance, we inserted the SIINFEKL peptide into influenza A virus (IAV)-negative strand gene segments. Although IAV genomic RNA is considered noncoding, there is a conserved, relatively long open reading frame present in segment 8, encoding a potential protein termed NEG8. The biosynthesis of NEG8 from IAV has yet to be demonstrated. Although we failed to detect NEG8 protein expression in IAV-infected mouse cells, cell surface K<sup>b</sup>- ...[more]