Ontology highlight
ABSTRACT:
SUBMITTER: Thawani A
PROVIDER: S-EPMC6082411 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Thawani Ankita A Sirohi Devika D Kuhn Richard J RJ Fekete Donna M DM
Cell reports 20180401 3
Zika virus (ZIKV) is associated with severe neurodevelopmental impairments in human fetuses, including microencephaly. Previous reports examining neural progenitor tropism of ZIKV in organoid and animal models did not address whether the virus infects all neural progenitors uniformly. To explore this, ZIKV was injected into the neural tube of 2-day-old chicken embryos, resulting in nonuniform periventricular infection 3 days later. Recurrent foci of intense infection were present at specific sig ...[more]