Ontology highlight
ABSTRACT:
SUBMITTER: Park HW
PROVIDER: S-EPMC6082816 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Park Heung Woo HW Kim Sang Heon SH Chang Yoon Seok YS Kim Sang Hoon SH Jee Young Koo YK Lee Ai Young AY Jang In Jin IJ Park Hae Sim HS Min Kyung Up KU
Allergy, asthma & immunology research 20180901 5
<h4>Purpose</h4>Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest the presence of genetic risk factors for SCARs other than drug-specific HLA. We aimed to identify a common genetic risk factor of SCARs across multiple drugs.<h4>Methods</h4>We performed 2 independent genome-wide association studies (GWASs). A total of 68 and 38 subjects wit ...[more]