Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC6085347 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Xu Xueyong X Li Yinghui Y Bharath Sakshibeedu R SR Ozturk Mert Burak MB Bowler Matthew W MW Loo Bryan Zong Lin BZL Tergaonkar Vinay V Song Haiwei H
Nature communications 20180809 1
Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-κB signaling to drive reactivation of the -146C>T mutant TERT promoter in multiple cancer types, but the mechanism underlying this cooperativity remains unknown. Here we report the crystal structure of a ternary p52/ETS1/-146C>T TERT promoter complex. While p52 needs to associate with consensus κB sites on the DNA to function during non-canonical NF-κB signaling, we show that p52 can activate the -146C>T TERT promote ...[more]