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Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches.

ABSTRACT: Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

SUBMITTER: Tan LL

PROVIDER: S-EPMC6085730 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches.

Tan Li-Li LL Li Haiwei H Qiu Yu-Chen YC Chen Dai-Xiong DX Wang Xin X Pan Rui-Yi RY Wang Yan Y Zhang Sean Xiao-An SX Wang Bo B Yang Ying-Wei YW

Chemical science 20141224 3

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature relea ...[more]

PMID: 30154997

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