Ontology highlight
ABSTRACT:
SUBMITTER: Augustine V
PROVIDER: S-EPMC6086126 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Augustine Vineet V Gokce Sertan Kutal SK Lee Sangjun S Wang Bo B Davidson Thomas J TJ Reimann Frank F Gribble Fiona F Deisseroth Karl K Lois Carlos C Oka Yuki Y
Nature 20180228 7695
Neural circuits for appetites are regulated by both homeostatic perturbations and ingestive behaviour. However, the circuit organization that integrates these internal and external stimuli is unclear. Here we show in mice that excitatory neural populations in the lamina terminalis form a hierarchical circuit architecture to regulate thirst. Among them, nitric oxide synthase-expressing neurons in the median preoptic nucleus (MnPO) are essential for the integration of signals from the thirst-drivi ...[more]