Ontology highlight
ABSTRACT:
SUBMITTER: Noh H
PROVIDER: S-EPMC6086585 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Noh Hyangsoon H Zhao Qingnan Q Yan Jun J Kong Ling-Yuan LY Gabrusiewicz Konrad K Hong Sungguan S Xia Xueqing X Heimberger Amy B AB Li Shulin S
Cancer letters 20180706
Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor. The current standard therapy, which includes radiation and chemotherapy, is frequently ineffective partially because of drug resistance and poor penetration of the blood-brain barrier. Reducing resistance and increasing sensitivity to chemotherapy may improve outcomes. Glioma stem cells (GSCs) are a source of relapse and chemoresistance in GBM; sensitization of GSCs to temozoliomide (TMZ), the primary chemotherapeuti ...[more]