Ontology highlight
ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC7578010 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Sun Jikui J Ma Quanfeng Q Li Banban B Wang Chen C Mo Lidong L Zhang Xuebin X Tang Fan F Wang Qiong Q Yan Xiaoling X Yao Xiuhua X Wu Qiaoli Q Shu Chang C Xiong Jinbiao J Fan Weijia W Wang Jinhuan J
Cell death & disease 20201022 10
Accumulating evidence indicates that the dysregulation of the miRNAs/mRNA-mediated carcinogenic signaling pathway network is intimately involved in glioma initiation and progression. In the present study, by performing experiments and bioinformatics analysis, we found that RPN2 was markedly elevated in glioma specimens compared with normal controls, and its upregulation was significantly linked to WHO grade and poor prognosis. Knockdown of RPN2 inhibited tumor proliferation and invasion, promote ...[more]