Ontology highlight
ABSTRACT:
SUBMITTER: Rehen SK
PROVIDER: S-EPMC60876 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Rehen S K SK McConnell M J MJ Kaushal D D Kingsbury M A MA Yang A H AH Chun J J
Proceedings of the National Academy of Sciences of the United States of America 20011101 23
A basic assumption about the normal nervous system is that its neurons possess identical genomes. Here we present direct evidence for genomic variability, manifested as chromosomal aneuploidy, among developing and mature neurons. Analysis of mouse embryonic cerebral cortical neuroblasts in situ detected lagging chromosomes during mitosis, suggesting the normal generation of aneuploidy in these somatic cells. Spectral karyotype analysis identified approximately 33% of neuroblasts as aneuploid. Mo ...[more]