Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC6088847 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Li Qianbin Q Al-Ayoubi Adnan A Guo Tailiang T Zheng Hui H Sarkar Aurijit A Nguyen Tri T Eblen Scott T ST Grant Steven S Kellogg Glen E GE Zhang Shijun S
Bioorganic & medicinal chemistry letters 20090918 21
A series of analogs of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione, a putative substrate-specific ERK1/2 inhibitor, were synthesized and biologically characterized in human leukemia U937 cells to define its pharmacophore. It was discovered that shift of ethoxy substitution from the 4- to the 2-position on the phenyl ring significantly improved functional activities of inhibiting cell proliferation and inducing apoptosis. This may provide access to a new lead for developing ...[more]