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T cell receptor repertoire profiling predicts the prognosis of HBV-associated hepatocellular carcinoma.


ABSTRACT: Tumor-infiltrating T cell repertoire has been demonstrated to be closely associated with anti-tumor immune response. However, the relationship between T cell repertoire in tumor tissue and prognosis has never been reported in Hepatocellular carcinoma (HCC). We performed the high-throughput T cell receptor (TCR) sequencing to systematically characterize the infiltrating T cell repertoires of tumor and matched adjacent normal tissues from 23 HBV-associated HCC patients. Significant differences on usage frequencies of some V?, J?, and V?-J? paired genes have been found between the 2 groups of tissue samples, but no significant difference of TCR repertoire diversity could be found. Interestingly, the similarity of TCR repertoires between paired samples or the TNM stage alone could not be helpful to evaluate the prognosis of patients very well, but their combination could serve as an efficient prognostic indicator that the patients with early stage and high similarity showed a better prognosis. This is the first attempt to assess the potential value of TCR repertoire in HCC prognosis, and our findings could serve as a complement for the characterization of TCR repertoire in HCC.

SUBMITTER: Lin KR 

PROVIDER: S-EPMC6089190 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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T cell receptor repertoire profiling predicts the prognosis of HBV-associated hepatocellular carcinoma.

Lin Kai-Rong KR   Deng Fei-Wen FW   Jin Ya-Bin YB   Chen Xiang-Ping XP   Pan Ying-Ming YM   Cui Jin-Huan JH   You Zhi-Xuan ZX   Chen Huan-Wei HW   Luo Wei W  

Cancer medicine 20180626 8


Tumor-infiltrating T cell repertoire has been demonstrated to be closely associated with anti-tumor immune response. However, the relationship between T cell repertoire in tumor tissue and prognosis has never been reported in Hepatocellular carcinoma (HCC). We performed the high-throughput T cell receptor (TCR) sequencing to systematically characterize the infiltrating T cell repertoires of tumor and matched adjacent normal tissues from 23 HBV-associated HCC patients. Significant differences on  ...[more]

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