Ontology highlight
ABSTRACT:
SUBMITTER: Fedry J
PROVIDER: S-EPMC6089408 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Fedry Juliette J Forcina Jennifer J Legrand Pierre P Péhau-Arnaudet Gérard G Haouz Ahmed A Johnson Mark M Rey Felix A FA Krey Thomas T
PLoS biology 20180813 8
HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the functional conformation of the HAP2 fusion loops has remained unknown, as the reported X-ray structure of Chlamydomonas reinhardtii HAP2 lacked this critical region. Here, we report a structure-guided alignment that reveals div ...[more]