Ontology highlight
ABSTRACT:
SUBMITTER: Johnson MR
PROVIDER: S-EPMC6089599 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
eLife 20180725
Regulating nuclear histone balance is essential for survival, yet in early <i>Drosophila melanogaster</i> embryos many regulatory strategies employed in somatic cells are unavailable. Previous work had suggested that lipid droplets (LDs) buffer nuclear accumulation of the histone variant H2Av. Here, we elucidate the buffering mechanism and demonstrate that it is developmentally controlled. Using live imaging, we find that H2Av continuously exchanges between LDs. Our data suggest that the major d ...[more]