Ontology highlight
ABSTRACT:
SUBMITTER: Macchia E
PROVIDER: S-EPMC6089965 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Macchia Eleonora E Manoli Kyriaki K Holzer Brigitte B Di Franco Cinzia C Ghittorelli Matteo M Torricelli Fabrizio F Alberga Domenico D Mangiatordi Giuseppe Felice GF Palazzo Gerardo G Scamarcio Gaetano G Torsi Luisa L
Nature communications 20180813 1
Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into a sequence of single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense a cue in a bulk milieu. Conceptualizing cells' ability to sense at the physical limit by means of highly-packed recognition elements, a millimetric sized field-effect-transistor is used to detect a single molecule. To this end, the gate is bio-func ...[more]