Ontology highlight
ABSTRACT:
SUBMITTER: Jongo SA
PROVIDER: S-EPMC6090339 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jongo Said A SA Shekalaghe Seif A SA Church L W Preston LWP Ruben Adam J AJ Schindler Tobias T Zenklusen Isabelle I Rutishauser Tobias T Rothen Julian J Tumbo Anneth A Mkindi Catherine C Mpina Maximillian M Mtoro Ali T AT Ishizuka Andrew S AS Kassim Kamaka Ramadhani KR Milando Florence A FA Qassim Munira M Juma Omar A OA Mwakasungula Solomon S Simon Beatus B James Eric R ER Abebe Yonas Y Kc Natasha N Chakravarty Sumana S Saverino Elizabeth E Bakari Bakari M BM Billingsley Peter F PF Seder Robert A RA Daubenberger Claudia C Sim B Kim Lee BKL Richie Thomas L TL Tanner Marcel M Abdulla Salim S Hoffman Stephen L SL
The American journal of tropical medicine and hygiene 20180621 2
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious <i>Plasmodium falciparum</i> (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 × 10<sup>5</sup> PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at 24 weeks against mosquito bite CHMI in U.S. adults and 52% (time to event) or 29% ...[more]