Ontology highlight
ABSTRACT:
SUBMITTER: Thadke SA
PROVIDER: S-EPMC6091552 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Thadke Shivaji A SA Perera J Dinithi R JDR Hridya V M VM Bhatt Kirti K Shaikh Ashif Y AY Hsieh Wei-Che WC Chen Mengshen M Gayathri Chakicherla C Gil Roberto R RR Rule Gordon S GS Mukherjee Arnab A Thornton Charles A CA Ly Danith H DH
Biochemistry 20180327 14
We report the development of a new class of nucleic acid ligands that is comprised of Janus bases and the MPγPNA backbone and is capable of binding rCAG repeats in a sequence-specific and selective manner via, inference, bivalent H-bonding interactions. Individually, the interactions between ligands and RNA are weak and transient. However, upon the installation of a C-terminal thioester and an N-terminal cystine and the reduction of disulfide bond, they undergo template-directed native chemical ...[more]