Ontology highlight
ABSTRACT:
SUBMITTER: Travers J
PROVIDER: S-EPMC6092330 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Travers Jared J Rochman Mark M Miracle Cora E CE Habel Jeff E JE Brusilovsky Michael M Caldwell Julie M JM Rymer Jeffrey K JK Rothenberg Marc E ME
Nature communications 20180814 1
IL-33 is an epithelium-derived, pro-inflammatory alarmin with enigmatic nuclear localization and chromatin binding. Here we report the functional properties of nuclear IL-33. Overexpression of IL-33 does not alter global gene expression in transduced epithelial cells. Fluorescence recovery after photobleaching data show that the intranuclear mobility of IL-33 is ~10-fold slower than IL-1α, whereas truncated IL-33 lacking chromatin-binding activity is more mobile. WT IL-33 is more resistant to ne ...[more]