Ontology highlight
ABSTRACT:
SUBMITTER: He Q
PROVIDER: S-EPMC6092349 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
He Qianqian Q Au Bijin B Kulkarni Madhura M Shen Yang Y Lim Kah J KJ Maimaiti Jiamila J Wong Cheng Kit CK Luijten Monique N H MNH Chong Han C HC Lim Elaine H EH Rancati Giulia G Sinha Indrajit I Fu Zhiyan Z Wang Xiaomeng X Connolly John E JE Crasta Karen C KC
Oncogenesis 20180815 8
Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid, cells contain an abnormal number of chromosomes and exhibit CIN. The post-mitotic cell fates following generation of different degrees of chromosome mis-segregation and aneuploidy are unclear. Here we used aneuploidy inducers, nocodazole and reversine, to create different levels of aneuploidy. A higher extent of aneupl ...[more]